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Synthesis of 5-Methyl-1,3-oxathiolane-based Nucleoside Analogues as Potential Antiviral Agents

[ Vol. 8 , Issue. 5 ]

Author(s):

Silvia Franchini, Annalisa Tait, Claudia Sorbi and Livio Brasili   Pages 769 - 778 ( 10 )

Abstract:


A series of 1,3-oxathiolane-based nucleoside analogs 5-methyl substituted was synthesized and tested as potential antiviral agents. Structural characterization and C2-C4 / C2-C5 relative stereochemistry assignments were performed by NMR experiments. All tested isomers were found to be inactive and cytotoxic.

Keywords:

5-methyl-1, 3-oxathiolanes, Antiviral, NMR, Nucleosides, Stereochemistry, Synthesis, AIDS, RNA, DNA, drugs

Affiliation:

Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Modena e Reggio Emilia, Via Campi 183, 41125 Modena, Italy.



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