Silvia Franchini, Annalisa Tait, Claudia Sorbi and Livio Brasili Pages 769 - 778 ( 10 )
A series of 1,3-oxathiolane-based nucleoside analogs 5-methyl substituted was synthesized and tested as potential antiviral agents. Structural characterization and C2-C4 / C2-C5 relative stereochemistry assignments were performed by NMR experiments. All tested isomers were found to be inactive and cytotoxic.
5-methyl-1, 3-oxathiolanes, Antiviral, NMR, Nucleosides, Stereochemistry, Synthesis, AIDS, RNA, DNA, drugs
Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Modena e Reggio Emilia, Via Campi 183, 41125 Modena, Italy.