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Metronidazole Esters: A New Class of Antiglycation Agents

[ Vol. 8 , Issue. 5 ]

Author(s):

Aurang Zeb, Imran Malik, Saima Rasheed, Muhammad Iqbal Choudhary and Fatima Z. Basha   Pages 846 - 852 ( 7 )

Abstract:


A series of metronidazole ester derivatives 1-34 has been synthesized with the aim of developing new leads with antiglycation activity. The in vitro evaluation of antiglycation potential of 1-34 showed that the ester derivatives 28, 16, and 3 have IC50 values 218.97 ± 2.5, 245.3 ± 5.1, and 278.6 ± 0.8 μM, respectively, comparable to the standard agent, rutin (IC50 = 294.5 ± 1.50 μM). The study identifies a new class of potent antiglycation agents. A structure-activity relationship has also been evaluated. All the compounds were characterized by using spectroscopic techniques, including 1H NMR, IR, and EI-MS.

Keywords:

AGE, Bovin serum albumin, Protein glycation, Inhibitors, Metronidazole, Ester derivatives, spectroscopic, NMR, Schiff bases, antifungal

Affiliation:

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.



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