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Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase β

[ Vol. 8 , Issue. 5 ]

Author(s):

Alexandra Zakharenko, Dmitry Sokolov, Olga Luzina, Maria Sukhanova, Svetlana Khodyreva, Olga Zakharova, Nariman Salakhutdinov and Olga Lavrik   Pages 883 - 893 ( 11 )

Abstract:


The influence of a number of usnic acid derivatives on auto(polyADP-ribosyl)ation catalyzed by PARP1 and DNA synthesis catalyzed by DNA polymerase β was studied. The derivatives of usnic acid containing aromatic substituents were shown to be moderate inhibitors of PARP1. The presence of both usnic acid tricyclic structure and aromatic substituent at any position of the molecule is a key factor for the inhibitory action. In the case of DNA polymerase β, no relationship between the structure and inhibitory properties has been found with the only exception. Derivatives with modified ring A showed mild activation of DNA synthesis catalyzed by DNA polymerase β.

Keywords:

DNA Polymerase β, PARP1, Poly(ADP-ribose)polymerase, Usnic acid, DNA, enzyme, antifungal, carcinoma, malignant, antitumor

Affiliation:

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Prospect Lavrentieva 9, Novosibirsk, 630090, Russia.



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