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Selective Inhibition of Inducible Nitric Oxide Synthase by Derivatives of Acetamidine

[ Vol. 8 , Issue. 6 ]

Author(s):

Cristina Maccallini, Antonia Patruno, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Sara Franceschelli, Letizia Giampietro, Simona Masella, Maria Luisa Tricca and Rosa Amoroso   Pages 991 - 995 ( 5 )

Abstract:


A new series of phenyl- and heteryl acetamidines were synthesized and evaluated as inhibitors of nitric oxide synthases (NOS). While the N-substitution of the acetamidine moiety with different heterocycles appears to completely destroy the activity, linking the phenyl core preserves it. Moreover, it was observed a strong dependence of the phenylacetamidines potency of action from the length of the alkyl chain that connects the aromatic ring to the acetamidine moiety.

Keywords:

Nitric oxide, Nitric oxide synthase, Selective inducible NOS inhibitors, Acetamidines, heterocycles, inorganic, neurodegenerative diseases, cytokines, polysaccharides, amino acid

Affiliation:

Dipartimento di Scienze del Farmaco, Universita di Chieti, via dei Vestini, 66100 Chieti, Italy.



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