Giorgio Biasiotto, Francesco Bertagna, Ugo Biasiotto, Carlo Rodella, Giovanni Bosio, Luigi Caimi, Giovanni Bettinsoli and Raffaele Giubbini Pages 1182 - 1189 ( 8 )
We proposed a method of synthesis to produce [11C]Choline using TRACERlab FXc module that utilized gas phase iodination. The product had radiochemical purity of 99.79 + 0.14 % and specific activity of 45.7 + 7.59 GBq/ mol. [11C]Choline did not have at the moment a specific monograph in European Pharmacopeia therefore we used, when possible, as quality controls reference the monograph of [18F]FDG and we proposed suitable methods to verify radiochemical purity and to quantify residual DMAE and choline amounts.
[11C]CH3I, [11C]Choline, gas phase iodination, prostate cancer, PET, quality controls, radiopharmaceutical, TRACERlab FXc
Lab. biotecnologie, Spedali Civili Brescia. P.le Spedali 1, 25123 Brescia; Italy.