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Description of High Purity and High Specific Activity of [11C]Choline Synthesis Using TRACERlab FXc Module, and Detailed Report of Quality Controls

[ Vol. 8 , Issue. 6 ]

Author(s):

Giorgio Biasiotto, Francesco Bertagna, Ugo Biasiotto, Carlo Rodella, Giovanni Bosio, Luigi Caimi, Giovanni Bettinsoli and Raffaele Giubbini   Pages 1182 - 1189 ( 8 )

Abstract:


We proposed a method of synthesis to produce [11C]Choline using TRACERlab FXc module that utilized gas phase iodination. The product had radiochemical purity of 99.79 + 0.14 % and specific activity of 45.7 + 7.59 GBq/ mol. [11C]Choline did not have at the moment a specific monograph in European Pharmacopeia therefore we used, when possible, as quality controls reference the monograph of [18F]FDG and we proposed suitable methods to verify radiochemical purity and to quantify residual DMAE and choline amounts.

Keywords:

[11C]CH3I, [11C]Choline, gas phase iodination, prostate cancer, PET, quality controls, radiopharmaceutical, TRACERlab FXc

Affiliation:

Lab. biotecnologie, Spedali Civili Brescia. P.le Spedali 1, 25123 Brescia; Italy.



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