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Design, Synthesis and Antimicrobial Properties of Novel 3,3a,4,5,6,7- Hexahydroindazole and Arylthiazolylpyrazoline Derivatives

[ Vol. 9 , Issue. 1 ]

Author(s):

Abha Bishnoi, Suruchi Singh, Anil K. Tiwari, Arun Sethi and Chandrakant Mani Tripathi   Pages 45 - 52 ( 8 )

Abstract:


A remarkable diastereoselective synthesis of some novel arylthiazolyl pyrazoline derivatives 3(a-l) is displayed which were evaluated for their in vitro antimicrobial activities. In particular, compounds 3e, 3g & 3l (MIC 12.5µ g /ml) showed good activity against S. aureus and compounds 3b & 3j (MIC 12.5 µ g / ml) against B. subtilis. Compounds 3g, 3i, 3j (MIC 12.5 µ g/ ml) and 3l (MIC 6.25 µg / ml) also displayed excellent antifungal activity against C. albicans. Of all the synthesized compounds, 3g and 3e exerted a wide range of antibacterial activities against entire tested gram positive (S. aureus and B. subtilis) and gram negative (E. coli and P. aeruginosa) bacterial strain except P. aeruginosa.

Keywords:

Antibacterial Activity, Antifungal Activity, Arylthiazolylpyrazoline, Cyclization, Diastereoselectivity, Heterocycles

Affiliation:

Department of Chemistry, Lucknow University, University Road, Lucknow-226 007, India



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