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Novel 2-hydrazino-pyrimidin-4(3H)-one Derivatives with Pseudofunctional- Similarity to Siderophores as Potential Antimycobacterial Agents

[ Vol. 9 , Issue. 1 ]

Author(s):

Ranjeet Bairwa, Nilesh R. Tawari, Amruta Alate, Swapnil Anam, Mariam S. Degani, Muktikant Ray and Ramakrishna M. G. Rajan   Pages 77 - 83 ( 7 )

Abstract:


Siderophores are small molecules produced by bacteria under iron-scarcity conditions faced by bacteria inside host. Sideophores bind iron with high affinity (Kd < 10-25 M) and are required for iron transport into the bacterial cell. Small molecules interfering with siderophore functioning can be promising anti-mycobacterial agents. Several molecules with hydrazone as a structural feature are known to have metal chelating property. This prompted us to investigate the metal chelating ability of 2-hydrazino-pyrimidin-4(3H)-one derivatives. In this light, a library of 22 novel molecules with 2- hydrazino-pyrimidin-4(3H)-one moiety was synthesized and the compounds were evaluated against M. tuberculosis under iron-limiting and iron-rich conditions. Interestingly, several molecules showed promising (MIC:<10 M) selective activity under iron scarcity conditions. Furthermore, compounds were found to be nontoxic at lower concentration in VERO cell lines using MTT assay. Taken together, we have discovered novel 2-hydrazino-pyrimidin-4(3H)-one molecules active against M. tuberculosis which can be developed as potent antimycobacterial agents.

Keywords:

2-hydrazino-pyrimidin-4(3H)-one, Iron scarcity, Siderophore, Antitubercular

Affiliation:

Institute of Chemical Technology, Nathalal Parikh Marg, Matunga, Mumbai-400019, India



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