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Novel C-9, 9'-O-acyl Esters of (-)-Carinol as Free-radical Scavengers and Xanthine Oxidase Enzyme Inhibitors: Synthesis and Biological Evaluation

[ Vol. 9 , Issue. 1 ]

Author(s):

Praveen Kumar Suryadevara, Hari Babu Tatipaka, Rama Subba Rao Vidadala, Ashok k Tiwari, Janaswamy Madhusudana Rao and Katragadda Suresh Babu   Pages 100 - 103 ( 4 )

Abstract:


New compounds with hydrophyllic esters of (-)-carinol were synthesized and evaluated as xanthine oxidase enzyme inhibitors and antioxidants. Aliphatic esterfication of C-9,9'-OH groups of (-)-carinol resulted in lowering antioxidant and xanthine oxidase inhibitory activities. However certain aromatic acyl esters considerably improved the xathine oxidase inhibition. Aromatic esterification with electron withdrawing substitutions would preferred for improvement in XOD inhibition while retaining radical scavenging activity, electron withdrawing substitution led to the loss of free radical scavenging property and neutral substituents decrease the enzyme inhibitory potential.

Keywords:

(-)-Carinol, Acyl derivatives, Xanthine oxidase inhibition, Free radical scavenging activity

Affiliation:

St. Jude Children’s Research Hospital, Department of Chemical Biology and Therapeutics, Memphis, TN-38105, USA



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