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Synthesis of Benzopyran Linked Pyrrolo[2,1-c][1,4]benzodiazepines as DNA-Binding and Potential Anticancer Agents

[ Vol. 9 , Issue. 2 ]

Author(s):

Ahmed Kamal, Rajender, Methuku Kashi Reddy, Vangala Santhosh Reddy and Gajjela Bharath Kumar   Pages 177 - 192 ( 16 )

Abstract:


A series of twelve benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized. They exhibit significant DNA-binding activity and excellent cytotoxic activity against various human cancer cell lines.

Keywords:

Cytotoxicity, DNA-Binding affinity, 2, 2-Dimethyl benzopyran, Pyrrolo[2, 1-c][1, 4]benzodiazepines and Piperazine

Affiliation:

Division of Organic Chemistry, Centre for Chemical Biology, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.



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