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Synthesis and Study the Antimicrobial Activity of Novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) Ethanamine Derivatives

[ Vol. 9 , Issue. 2 ]

Author(s):

Ravindra M. Kumbhare, K. Vijay Kumar, Tulshiram L. Dadmal, Umesh B. Kosurkar and K. Appalanaidu   Pages 287 - 293 ( 7 )

Abstract:


A series of novel 2-(1H-indol-3-yl)-N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives (5a-o) were synthesized by cyclization of corresponding 1-(2-(1H-indol-3-yl) ethyl)-3-phenylthiourea 3 with 2-bromoacetophenone. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria and Gramnegative bacteria. In vitro antifungal activity also determined against the five fungal species. Structures of the synthesized compounds were established by elemental analysis and spectral data.

Keywords:

Ethanamine derivatives, Tryptamine, Thiourea, 2-Bromoacetophenone, Antibacterial, Antifungal

Affiliation:

Division of Fluoroorganic, Indian Institute of Chemical Technology, Hyderabad-500607, India.



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