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Synthesis and Study the Antimicrobial Activity of Novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) Ethanamine Derivatives

[ Vol. 9 , Issue. 2 ]


Ravindra M. Kumbhare, K. Vijay Kumar, Tulshiram L. Dadmal, Umesh B. Kosurkar and K. Appalanaidu   Pages 287 - 293 ( 7 )


A series of novel 2-(1H-indol-3-yl)-N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives (5a-o) were synthesized by cyclization of corresponding 1-(2-(1H-indol-3-yl) ethyl)-3-phenylthiourea 3 with 2-bromoacetophenone. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria and Gramnegative bacteria. In vitro antifungal activity also determined against the five fungal species. Structures of the synthesized compounds were established by elemental analysis and spectral data.


Ethanamine derivatives, Tryptamine, Thiourea, 2-Bromoacetophenone, Antibacterial, Antifungal


Division of Fluoroorganic, Indian Institute of Chemical Technology, Hyderabad-500607, India.

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