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The Synthesis, Structural Study and Anticancer Activity Evaluation of Emodin Derivatives Containing Conjugative Groups

[ Vol. 9 , Issue. 4 ]

Author(s):

Wang Wen-Feng, Zhang Feng-Sen, Zhao Wen-Na, Bai Ze-Dong, Yang Hui-Jun, Shao Jing-Wei and Yuan Yao-Feng   Pages 545 - 552 ( 8 )

Abstract:


Eight new emodin derivatives that contain large conjugative system have been synthesized and their anticancer activities also have been evaluated. The result shows that large conjugative system can not enhance the anticancer activities of emodin derivatives, but the introduction of an alkylating center can make emodin derivative effective against cancer cell lines. Compound 12 has the highest alkylating ability, but its anticancer activity is not remarkable, which indicates that there is not a direct correlation between the chemical reactivity of the alkylating agent and the toxic effects.

Keywords:

Emodin derivatives, anticancer activity, synthesis, conjugative groups

Affiliation:

College of Chemistry and Chemical Engineering, Fuzhou University, Fujian, 350108, P. R. China.



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