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Synthesis, Characterization of (Z)-N-(1-(2-(2-amino-3-(dimethylamino) methyl)phenyl)-5-phenyl-1,3,4, oxadiazol-3(2H)-yl)ethanone Analogs as Potent Antimicrobial and Hydrogen Peroxide Scavenging Agents

[ Vol. 9 , Issue. 5 ]


Manav Malhotra, Vikramdeep Monga, Rajiv Sharma, Kapendra Sahu, Gaurav Sharma, Jainendra Jain and Aakash Deep   Pages 710 - 717 ( 8 )


A series of (Z)-N-(1-(2-(2-amino-3-((dimethylamino) methyl) phenyl)-5-phenyl-1,3,4,oxadiazol-3(2H)- yl)ethanone derivatives was prepared and studied for its antimicrobial and antioxidant activities. Among the synthesized derivatives, compounds (7c) (Z)-N-(1-(2-(2-amino-3-((dimethylamino)methyl)phenyl)-5-phenyl-1,3,4-oxadiazol-3(2H)- yl)ethylidene)-4-chloroaniline, (7g) (Z)-N-(1-(2-(2-amino-3-((dimethylamino)methyl)phenyl)-5-phenyl-1,3,4-oxadiazol- 3(2H)-yl)ethylidene)-4-nitroaniline and (7i) (Z)-N-(1-(2-(2-amino-3-((dimethylamino)methyl)phenyl)-5-phenyl-1,3,4- oxadiazol-3(2H)-yl)ethylidene)-4-methoxyaniline were found to be the most effective antimicrobial compounds. While the compounds 7c and 7g were the most potent antioxidant compounds with significant hydrogen peroxide scavenging activity.


Mannich Bases, Lipophilicity, 1, 3, 4-Oxadiazoles, Antimicrobial and antioxidant activities.


Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.

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