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Synthesis and Biological Activity of Nitric Oxide-releasing Derivatives of Ferulic Acid as Potential Agents for the Treatment of Chronic Kidney Diseases

[ Vol. 9 , Issue. 6 ]

Author(s):

Hao-Ran Liu, Ying Liu, Yan-Lai Li, Min-You Qi and Wu-Kun Liu   Pages 875 - 880 ( 6 )

Abstract:


In order to search for novel potential agents for the treatment of chronic kidney diseases (CKD), nitric oxide (NO)-releasing derivatives (5a-c) of ferulic acid were synthesized and characterized by MS, 1H NMR, and elementary analysis. They showed different NO-releasing rate in the absence or presence of L-cysteine in vitro. In the adenine induced CKD rats, these compounds revealed reno-protective effect via lowering blood urea nitrogen (BUN), creatinine (Cr) in serum and malondialdehyde (MDA) in kidney, increasing NO and superoxide dismutase (SOD) level in kidney. Among them, 3-methoxy-4-(nitrooxy)ethoxy cinnamic acid (5a) was confirmed to have a higher NO-releasing rate in vitro and better effect in ameliorating adenine-induced kidney damage in rats.

Keywords:

Ferulic Acid, Nitric Oxide Donor; Chronic Kidney Disease, Adenine.

Affiliation:

Department of pharmacy, College of Chemical and Chemistry Engineering, Hunan University, Changsha 410082, P.R.China and Institute of Pharmacy, Free University of Berlin, Konigin-Luise-Str, 2+4, 14195 Berlin, Germany.



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