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Design, Synthesis and Cytotoxic Activity Evaluation of New Aminosubstituted Benzofurans

[ Vol. 10 , Issue. 6 ]

Author(s):

Konstantinos Daniilides, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos, Pinelopi Samara and Ourania Tsitsilonis   Pages 619 - 627 ( 9 )

Abstract:


A number of new aminosubstituted benzofuran analogues have been prepared and their cytotoxic/cytostatic activity was investigated against five human tumor cell lines (MCF-7, SKBR3, SKOV3, HCT-116 and HeLa). Certain compounds showed noticeable tumor cell growth inhibition, indicative of possible structure-activity relationships.

Keywords:

Benzofurans, Cytotoxicity, Heterocycles, Sonogashira cross-coupling, Wadsworth-Emmons reaction.

Affiliation:

University of Athens, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Panepistimiopolis- Zografou, Athens 15771, Greece.

Graphical Abstract:



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