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Synthesis of 1H-1,2,3-triazoles and Study of their Antifungal and Cytotoxicity Activities

[ Vol. 9 , Issue. 8 ]

Author(s):

Iara F. da Silva, Prisicila R.C. Martins, Emanuelly G. da Silva, Sabrina B. Ferreira, Vitor F. Ferreira, Karen Regina C. da Costa, Marne C. de Vasconcellos, Emerson S. Lima and Fernando de C. da Silva   Pages 1085 - 1090 ( 6 )

Abstract:


We report herein the results of antifungal activity of fifteen 1,2,3-triazoles against Candida albicans, Candida krusei, Candida parapsilosis, Candida kefyr, Candida tropicalis, Candida dubliniensis, Tricophyton rubrum, Microporum canis and Aspergillus niger. All of the 1,2,3-triazoles were prepared from 1,3-dipolar cyclizations between aryl azides and alkynes catalyzed by Cu(I), and several of the compounds exhibited antifungal activity with low cytotoxicity. The results demonstrated the potential and importance of developing new 1,2,3-triazoles compounds with antifungal activity.

Keywords:

Antifungal activity, Aspergillus spp., Candida spp., cytotoxicity, Microporum canis, 1H-1, 2, 3-Triazoles, Tricophyton rubrum.

Affiliation:

Universidade Federal Fluminense, Departamento de Quimica Organi ca, Intituto de Quimica, de Valonguinho, 24020, Niteroi, RJ, Brazil.



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