Iyadh Aouani, Karima Lahbib and Soufiane Touil Pages 206 - 213 ( 8 )
Herein we report an efficient, simple and green synthesis of novel types of α-hydroxyphosphonates bearing a nitrile group, from the reaction of γ-ketonitriles with dialkyl phosphites in the presence of magnesium oxide as solid support, under solvent-free conditions. All the title compounds were screened for their antioxidant activity by 1,1-diphenyl-2- picrylhydrazyl (DPPH), hydroxyl radical, reducing power and ferrous ion chelating (FIC) methods and they showed significant antioxidant activity.
α-Hydroxyphosphonates, γ-cyano-α-hydroxyphosphonates, γ-ketonitriles, green synthesis, antioxidant activity.
Laboratory of Heteroatom Organic Chemistry, Department of Chemistry, Faculty of Sciences of Bizerta, University of Carthage, 7021-Jarzouna, Tunisia.