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Design, Synthesis, and Antitumor Activity of Novel Acylate of 6-OH at 1- O-acetylbritannilactone

[ Vol. 11 , Issue. 2 ]


Shouxin Liu, Jun Feng, He Liu, Junzhang Li and Xia Tian   Pages 200 - 205 ( 6 )


N-(α-Alkyloxime-3-phenylpropionyl) proline was designed and synthesized as an acylating agent to modify the 6-OH of 1-O-acetylbritannilactone. Eight intermediates and eight target compounds were obtained. The structures of sixteen novel compounds were characterized by 1HNMR, IR and HRMS. The activities against HL-60 and Bel-7402 cell lines were tested, the IC50 values of compound IVg were 2.7 μM and 4.3 μM, respectively.


Acylation compound, antitumor, britannilactone, synthesis.


State Key Laboratory Breeding Base, Hebei Laboratory of Molecular Chemistry for Drug, College of Chemical and Pharmaceutical Engineering, Hebei University of Science & Technology, Shijiazhuang 050018, P.R. China.

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