Mohammad Abrar Alam, Yeruva Suman Reddy and Mohamad Akbar Ali Pages 271 - 285 ( 15 )
Aberrant regulation of epigenetic pathways causes many diseases including aging, cancer, diabetes, viral pathogenesis, drug addiction etc. and it has been estimated that epigenetic aberrations are at least ten to forty times more frequent in cancers than genetic mutations. Present epigenetic modulators hold great promise for a variety of diseases, and important tools for biological applications but these molecules have many dose limiting toxicities and existing paradigms lack desired efficacy. Synthesis and biological studies of epigenetic modulators have been attractive targets for medicinal and synthetic organic chemists in recent years. This review article provides deep insight into the new and under explored epigenetic modulators. These molecules have the potential to be used as unique template with novel pharmacophores.
Aging, epigenetics, cancer, diabetes, gene, and histone.
Department of Chemistry and Biochemistry Rowan University, Glassboro, NJ 08028, USA.