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Design, Synthesis and Antimicrobial Evaluation of Methyl Pyridyl-2,4- Dioxobutanoates and Some New Derived Ring Systems

[ Vol. 11 , Issue. 4 ]


Perihan A.S. Elzahhar, Raafat Soliman, Soad A.M. El-Hawash, Hanan M.A. Ragab, Amal M. Youssef and Abeer E. Abdel Wahab   Pages 407 - 414 ( 8 )


This work describes the synthesis of new series of compounds derived from methyl pyridyl- 2,4-dioxobutanoates that contain pyridine ring attached to substituted bioactive heterocyclic moieties in order to investigate their preliminary in vitro antibacterial and antifungal activities. The results revealed that most of the tested compounds exhibited significant activity against P. aeruginosa. and E. coli. They also displayed considerable activity against S. aureus and B. subtilis. On the other hand, the compounds displayed moderate antifungal activity.


Thiazolidin-4-one, 3, 4-dihydroquinoxalinones, 3, 4-dihydrobenzo[b][1, 4] oxazinone, 1, 2-diazepine, piperazin-2- one, synthesis, antibacterial activity, antifungal activity.


Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt.

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