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Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane

[ Vol. 11 , Issue. 8 ]

Author(s):

Jeremy Ricci, Dongguk Min, Miyeon Oh, Hyenchong Lim, Won-Yoon Chung, Kwang-Kyun Park and Mankil Jung   Pages 747 - 752 ( 6 )

Abstract:


Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.

Keywords:

Daumone, glycolipid, antiangiogenic activity, synthesis.

Affiliation:

Department of Chemistry, Yonsei University, Seoul 120–749, Korea.

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