Submit Manuscript  

Article Details


α¯ Aminoisobutyric Acid Leads a Fluorescent syn-bimane LASER Probe Across the Blood-brain Barrier

[ Vol. 12 , Issue. 1 ]

Author(s):

Inbal Lapidot, Danny Baranes, Albert Pinhasov, Gary Gellerman, Amnon Albeck, Flavio Grynszpan and Shimon E. Shatzmiller   Pages 48 - 53 ( 6 )

Abstract:


Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.

Keywords:

Blood-brain barrier, fluorescence microscopy, fluorescent probe, LASER dye, syn-bimane.

Affiliation:

Department of Biological Chemistry, Ariel University, Ariel 40700, Israel.

Graphical Abstract:



Read Full-Text article