Inbal Lapidot, Danny Baranes, Albert Pinhasov, Gary Gellerman, Amnon Albeck, Flavio Grynszpan and Shimon E. Shatzmiller Pages 48 - 53 ( 6 )
Penetration of the blood brain barrier (BBB) by appropriate fluorescent probes remains a challenge in optical imaging and diagnostics. We designed, synthesized and observed the in vivo BBB penetration of a LASER syn-bimane probe. Results demonstrate that the Aib transporter unit in our probe may lead a fluorescent bimanyl moiety across the BBB.
Blood-brain barrier, fluorescence microscopy, fluorescent probe, LASER dye, syn-bimane.
Department of Biological Chemistry, Ariel University, Ariel 40700, Israel.