Kaliappan Ilango, Parthiban Valentina, Gajendra Kumar, Dushyant Dixit, Shrikant Nilewar and Muthu K. Kathiravan Pages 753 - 763 ( 11 )
A series of twenty molecules belonging to 2,5-disubstituted-1,3,4-oxadiazole derivatives of Diclofenac and Naproxen were designed, synthesized and their structures were confirmed by spectroscopy. The target compounds were evaluated for anti-inflammatory and analgesic activity. The result indicates that the compounds 12, 4, 6, 7 and 15 were found to have good analgesic and anti-inflammatory activities, while the compounds 12 and 14 were found to have good analgesic and the compound 22 were found to have good anti-inflammatory activities. HQSAR and Topomer QSAR studies were performed to get insights in the structures contributing for biological activity. The compounds bearing mono-substitution such as Cl, OCH3 and NO2 in the phenyl ring were found to have maximum analgesic and anti-inflammatory activities
1, 3, 4-oxadizole, NSAID, anti-inflammatory, analgesic, QSAR.
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur - 603 203, Kancheepuram (Dt), Tamil Nadu, India.