Yun Wei, Qutong Zheng, Guotao Tang, Chen Song, Guan Wang, Yinxiang Zhang, Yan Xiao, Xianliang Zeng, Zongbao Wang, Jichang Xiao and Xing Zheng Pages 441 - 447 ( 7 )
A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2μM, it was better than 5-FU (59.3μΜ, 18.4μM respectively).
Anti-thyroid cancer, activities, Baker-Venkataraman reaction, flavonoids, iodo-chrysin derivatives, MTT method.
Institute of Pharmacy & Pharmacology, University of South China, Hengyang, 421001, China