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Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives

[ Vol. 12 , Issue. 5 ]

Author(s):

Yun Wei, Qutong Zheng, Guotao Tang, Chen Song, Guan Wang, Yinxiang Zhang, Yan Xiao, Xianliang Zeng, Zongbao Wang, Jichang Xiao and Xing Zheng   Pages 441 - 447 ( 7 )

Abstract:


A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2μM, it was better than 5-FU (59.3μΜ, 18.4μM respectively).

Keywords:

Anti-thyroid cancer, activities, Baker-Venkataraman reaction, flavonoids, iodo-chrysin derivatives, MTT method.

Affiliation:

Institute of Pharmacy & Pharmacology, University of South China, Hengyang, 421001, China



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