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Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3- trizole-4-carboxyl Amide Analogues

[ Vol. 12 , Issue. 3 ]


Zhen-Jun Wang, Hui-Hui Yang, Lei Tian and Wei-Guang Zhao   Pages 290 - 295 ( 6 )


Succinate dehydrogenase inhibitors (SDHIs) are fungicides with an amide bond widely used to control plant diseases caused by phytopathogenic fungi. Because of broad spectrum activity of new SDHIs, they have attracted wide attention from the research community. A series of structurally novel SDHIs with a bioactive 1,2,3-triazole moiety were designed and synthesized. Bioactivity screening showed that some of designed N-phenethyl-1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Sclerotinia sclerotiorum and Botrytis cinerea, while some of Nbenzyl- 1,2,3-trizole-4-carboxyl amide analogues exhibited good fungicidal activities toward Phytophthora capsici and Cercospora arachidicola. EC50 value of compound 5d against Cercospora arachidicola (6.6 µg/mL) was lower than that of chlorothalonil (12.3 µg/mL).


Succinate dehydrogenase inhibitors, 1, 2, 3-Triazole, fungicide, fungicidal activity relationship, synthesis.


Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, China

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