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Antiplasmodial Limonoids from Trichilia rubescens (Meliaceae)

[ Vol. 12 , Issue. 7 ]

Author(s):

Tsamo T. Armelle, Nangmo K. Pamela, Mkounga Pierre, Ingrid B. Müller, Kirk Marat, Gabriele Sass and Nkengfack A. Ephrem   Pages 655 - 661 ( 7 )

Abstract:


Two new limonoids, named rubescins D-E (1-2) along with eight known compounds, including five havanensin type limonoids, TS1 (3), TS3 (4), rubescins A-C (5-7) and three known phytosterols, -sitosterol, stigmasterol and its 3 -O-glucopyranoside derivative were isolated from the roots and stem bark of Trichilia rubescens, collected from Cameroon. The structures of the new compounds were determined by detailed analyses of 1D and 2D NMR spectra, in combination with high-resolution mass spectrometry data and by comparison with related data from literature. Anti-plasmodial activities of some of the isolated limonoids 1, 2, 4, 6 and 7 were evaluated against erythrocytic stages of strain 3D7 Plasmodium falciparum. Compounds 2 and 4 exhibited significant anti-plasmodial in vitro activity with IC50 values of 1.13 and 0.79 M, respectively.

Keywords:

Trichilia rubescens, meliaceae, limonoids, nortriterpenoid, anti-plasmodial activity.

Affiliation:

Department of Organic Chemistry, University of Yaounde I, P.O. Box 812 Yaounde, Cameroon.

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