Piotr Kawczak and Tomasz Baczek Pages 404 - 411 ( 8 )
Mass spectrometry (LC-MS or LC-MS/MS) appears in all phases of drug discovery and drug development areas. Starting with the screening and identification of a therapeutic agent and further measuring its in vivo and in vitro properties include: absorption, distribution, metabolism, excretion and toxicity (ADMET) and also pharmacokinetic (PK) and pharmacodynamic (PD) quantitative parameters of drug candidate. Mass spectrometry also serves as a necessary tool also to confirm purity and stability of analyzed new chemical entities (NCEs)/new molecular entities (NMEs) as well as for the analysis of degradation products from the synthesis and following on every stages of drug discovery.
Mass spectrometry, LC-MS, drug discovery, drug development, ADMET.
Department of Pharmaceutical Chemistry, Medical University of Gdansk, Gdansk 80-416, Poland.