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Gastrointestinal Motility and Acute Toxicity of Pistagremic Acid Isolated from the Galls of Pistacia integerrima

[ Vol. 13 , Issue. 3 ]

Author(s):

Abdur Rauf*, Tareq Abu-Izneid, Aneela Maalik, Saud Bawazeer, Ajmal Khan, Taibi Ben Hadda, Haroon Khan, Mohamed Fawzy Ramadan, Imran Khan, Mohammad S. Mubarak, Ghias Uddin, Alia Bahadar and Umar Farooq   Pages 292 - 294 ( 3 )

Abstract:


Background: Pistacia integerrima has many medicinal uses in therapeutic as well as folk medicine. P. integerrima has been used for the treatment of different ailments such as blood purifier, anti-inflammatory, and as remedy for gastrointestinal disorders such as vomiting and diarrhea, expectorant, cough, asthma and fever.

Objective: The main objective of this research work was to evaluate the effect of pistagremic acid (PA) isolated from the galls of Pistacia integerima in acute toxicity and gastrointestinal (GIT) motility tests.

Methods: Compound 1 namely pistagremic acid (PA) (at 10, 50, 100 mg/kg i.p) were assessed for their in-vivo gastrointestinal motility test using charcoal screening model.

Results: Results revealed that pretreatment of PA exhibited substantial safety in acute toxicity test up to the dose of 500 mg/kg p.o. However, when studied in charcoal meal GI transit test, PA caused significant (p < 0.05) attenuation of GIT motility and an increase in intestinal transit time, comparable to atropine (a muscarinic receptor blocking agent).

Conclusion: In conclusion, PA displayed a strong dose-dependent reduction in GIT motility with considerable safety.

Keywords:

Pistacia integerima, pistagremic acid, acute toxicity, GIT motility test, dose-dependent reduction, charcoal meal.

Affiliation:

Department of Chemistry, University of Swabi, Ambar-23561, Khyber Pakhtunkhwa, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, P.O. Box 42, Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah, P.O. Box 42, Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, LCM Laboratory, University of Mohamed 1st, Faculty of Sciences, Oujda 60000, Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Biochemistry Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, Zagazig, Department of Pharmacy, University of Swabi, Ambar-23561, Khyber Pakhtunkhwa, Department of Chemistry, The University of Jordan, Amman 11942, Institute of Chemical Sciences, University of Peshawar, Peshawar, KPK, Department of Botany, Abdul Wali Khan University, Mardan 23200, Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060

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