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The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery

[ Vol. 13 , Issue. 8 ]

Author(s):

Simone Q. Pantaleao, Drielli G.V. Fujii, Vinicius G. Maltarollo, Danielle da C. Silva, Gustavo H.G. Trossini, Karen C. Weber, Luis P.B. Scott and Kathia M. Honorio*   Pages 706 - 720 ( 15 )

Abstract:


Background: Due to the increasing number of diabetes cases worldwide, there is an international concern to provide even more effective treatments to control this condition.

Methods: This review brings together a selection of studies that helped to broaden the comprehension of various biological targets and associated mechanisms involved in type 2 diabetes mellitus.

Results: Such studies demonstrated that QSAR techniques and virtual screenings have been successfully employed in drug design projects.

Conclusions: Therefore, the main goal of this review is to give the state-of-art for the development of new drugs for the treatment of type 2 diabetes mellitus and to evaluate how computational tools, such as virtual screening and 3D-QSAR, can aid the development of new drugs with reduced adverse side effects.

Keywords:

Biological targets, computational chemistry, diabetes, drug design, QSAR, virtual screening.

Affiliation:

Federal University of ABC, 09210-170, Santo Andre, SP, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, 05508-000, Sao Paulo, SP, Department of Pharmaceutical Products, Faculty of Pharmacy, Federal University, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Federal University of ABC, 09210-170, Santo Andre, SP, Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of Sao Paulo, 05508-000, Sao Paulo, SP, Department of Chemistry, Federal University of ParaĆ­ba, 13083-970, Joao Pessoa, PB, Federal University of ABC, 09210-170, Santo Andre, SP, School of Arts, Sciences and Humanities, University of Sao Paulo, 03828-000, Sao Paulo, SP

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