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Synthesis & Anticancer Evaluation of New Substituted 2-(3,4- Dimethoxyphenyl)benzazoles

Author(s):

Cigdem Karaaslan , Yalcin Duydu, Aylin Ustundag , Can Ozgur Yalcin, Banu Kaskatepe and Hakan Goker*   Pages 1 - 11 ( 11 )

Abstract:


Background: The benzazole nucleus is found in many promising small molecules such as anticancer and antibacterial agents. Bendamustine (Alkylating agent), Nocodazole (Mitotic inhibitor), Veliparib (PARP inhibitor), and Glasdegib (SMO inhibitor) are being clinically used as anticancer therapeutic which bear benzimidazole moiety. Based on the principle of bioisosterism, in the present work, 23 compounds belonging to 2-(3,4-dimethoxyphenyl)benzazoles and imidazopyridine series were synthesized and evaluated for their anticancer and antimicrobial activities. Objective: A series of new 2-(3,4-dimethoxyphenyl)-1H-benz(or pyrido)azoles were synthesized and evaluated for their anticancer and antimicrobial activities. Method: N-(5-chloro-2-hdroxyphenyl)-3,4-dimethoxybenzamide 1, was obtained by the amidation of 2-hydroxy-5-chloroaniline with 3,4-dimethoxybenzoic acid by using 1,1'-carbonyldiimidazole. Cyclization of 1 to benzoxazole derivative 2, was achieved by p-toluenesulfonic acid. Other 1H-benz(or pyrido)azoles were prepared by the reaction between 2-aminothiophenol, ophenylenediamine, o-pyridinediamine with sodium metabisulfite adduct of 3,4-dimethoxybenzaldehyde. The NMR assignments of the dimethoxy groups were established by the NOESY spectra. Results: Compound 12, bearing two chlorine atoms at the 5(4) and 7(6) positions of the benzene moiety of benzimidazole was found the most potent analogue against A549 cells with the GI50 value of 1.5

Keywords:

3, 4-Dimethoxyphenyl, NOESY, 1H-benzimidazole, imidazopyridine, benzoxazole, benzothiazole

Affiliation:

Department of Pharmaceutical Chemistry, Ankara University, Ankara, Department of Pharmaceutical Toxicology, Ankara University, Ankara, Department of Pharmaceutical Toxicology, Ankara University, Ankara, Department of Pharmaceutical Toxicology, Ankara University, Ankara, Department of Microbiology, Ankara University, Ankara, Department of Pharmaceutical Chemistry, Ankara University, Ankara



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