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Synthesis and Evaluation of the in vitro Antimicrobial Activity of Triazoles, Morpholine and Thiosemicarbazones

[ Vol. 15 , Issue. 1 ]

Author(s):

Felipe R. S. Santos, Jessica T. Andrade, Carla D. F. Sousa, Joice S. Fernandes, Lucas F. Carmo, Marcelo G. F. Araujo, Jaqueline M. S. Ferreira and Jose A. F. P. Villar*   Pages 38 - 50 ( 13 )

Abstract:


Background: Microbial infections is a global public health problem. The aim of this work was to synthesize and evaluate the antimicrobial activity of novel triazoles, morpholines and thiosemicarbazones.

Methods: Compounds were synthesized using 2,4-Dihydroxyacetophenone and 4-hydroxybenzaldehyde as starting materials. The antimicrobial activity of these compounds against bacteria and yeast was evaluated by the broth microdilution method.

Results: The proposed route for synthesis gave high to moderate yields, moreover these compounds were successfully characterized by

Keywords:

Triazoles, morpholines, thiosemicarbazones, antifungal, antibacterial.

Affiliation:

Laboratorio de Sintese Orgânica e Nanoestruturas, Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis,35501-296, Laboratorio de Microbiologia, Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis,35501-296, Laboratorio de Microbiologia, Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis,35501-296, Laboratorio de Sintese Orgânica e Nanoestruturas, Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis,35501-296, Laboratorio de Sintese Orgânica e Nanoestruturas, Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis,35501-296, Laboratorio de Farmacologia, Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis,35501-296, Laboratorio de Microbiologia, Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis,35501-296, Laboratorio de Sintese Orgânica e Nanoestruturas, Universidade Federal de Sao Joao del-Rei, Campus Centro-Oeste Dona Lindu, Divinopolis,35501-296



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