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Essential Oil from Lippia origanoides (Verbenaceae): Haemostasis and Enzymes Activity Alterations

Author(s):

Maria Luisa Teixeira, Silvana Marcussi, Danubia Aparecida de Carvalho Selvati Rezende, Maisa Lamounier Magalhaes, David Lee Nelson and Maria das Gracas Cardoso   Pages 1 - 8 ( 8 )

Abstract:


Background: The search for natural inhibitors of snake venom toxins is essential to supplement or even replace the serum therapy. The aim of this work was to evaluate the pharmacological properties of essential oil from Lippia origanoides Kunth. (Verbenaceae). Methods: The oil was extracted by hydrodistillation and the constituents were identified and quantified by GC-MS and GC-FID. The essential oil from L. origanoides was evaluated in hemolysis tests, on the activities of phospholipases A2 and serine proteases and in coagulation and thrombolysis induced by different snake venoms. Results: The major constituents of essential oil were carvacrol, p-cymene,

Keywords:

Natural products, Oxygenated monoterpenes, Hemostatic action, Enzyme inhibitors.

Affiliation:

Department of Chemistry, Federal University of Lavras, CP: 3037, 37200-000, Lavras, Department of Chemistry, Federal University of Lavras, CP: 3037, 37200-000, Lavras, Department of Chemistry, Federal University of Lavras, CP: 3037, 37200-000, Lavras, Department of Food Science, Federal University of Lavras, CP: 3037, 37200-000, Lavras, Federal University of Vales de Jequitinhonha e Mucuri, Diamantina, Department of Chemistry, Federal University of Lavras, CP: 3037, 37200-000, Lavras



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