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Therapeutic effects of Ziziphus jujuba Mill. fruit in traditional and modern medicine: a review

Author(s):

Zahra Sobhani , Sara Nikoofal-Sahlabadi, Mohammad Sadegh Amiri, Mahin Ramezani, Seyed Ahmad Emami and Amirhossein Sahebkar*  

Abstract:


Ziziphus jujuba Mill. belonging to the Rhamnaceae family, has been consumed since ancient times as a medicine and food. In the different traditional medical schools, Z. jujuba has been used to treat various diseases such as respiratory system diseases (asthma, cough, and laryngitis), gastrointestinal problems (constipation, colitis and liver diseases), as well as, cardiovascular and genitourinary system diseases. From the perspective of Islamic traditional medicine (ITM) Z.jujuba fruit is an emollient, laxative, and maturative, it can purify blood and improve blood circulation, relieve internal heat and reduce inflammation. Some therapeutic uses of Z. jujuba such as antibacterial, antioxidant, sedative, hepato-protective, anti-hyperglycemic, and anti-hyperlipidemic activities have been shown in modern pharmacological studies. In the current study, traditional and ethno-medicinal uses, botany, phytochemistry and pharmacological activities of Z. jujuba were reviewed.

Keywords:

Traditional medicine, Ziziphus jujuba, Rhamnaceae, jujube, food, flavonoids

Affiliation:

Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Department of Pharmaceutics, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Department of Biology, Payame Noor University, Tehran, Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad



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