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Oreganum Vulgare: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells

Author(s):

Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi and Mubashir Hussain Masoodi*   Pages 1 - 11 ( 11 )

Abstract:


Background: Inflammation involves a dynamic network that is highly regulated by signals that initiate the inflammation process as well as signals that downregulate it. However, an imbalance between the two leads to tissue damage. Throughout the world, inflammatory disease becomes common in the aging society. The drugs which are used clinically suffer serious side effects. Natural products or compounds derived from natural products show diversity in structure and play an important role in drug discovery and development.

Objective: Oreganum Vulgare is used in traditional medicine for various ailments including respiratory and rheumatic disorders, severe cold, suppression of tumors. The current study aims to evaluate the anti-inflammatory potential by evaluating various in-vitro parameters.

Results: The extracts (OVEE, OVEAF) as well as the isolated compound(OVRA)of Oreganum Vulgare inhibit the proinflammatory cytokines (IL-6 and TNF-α) and NO without affecting cell viability.

Conclusion: our study established that the leaf extracts of Oreganum Vulgare exhibits anti-inflammatory activity and thus confirm its importance in traditional medicine.

Keywords:

Phytoconstituents, IL-6, LPS, traditional medicine, Kashmir, anti-inflammatory.

Affiliation:

Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar 190006, Kashmir, Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, JammuTawi, Jammu 180001, Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali 160062, Punjab, Department of Molecular Science and Technology, Ajou University, Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, JammuTawi, Jammu 180001, Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali 160062, Punjab, Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, JammuTawi, Jammu 180001, Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, JammuTawi, Jammu 180001, Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, JammuTawi, Jammu 180001, Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali 160062, Punjab, Department of Molecular Science and Technology, Ajou University, Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, JammuTawi, Jammu 180001



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