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Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

[ Vol. 17 , Issue. 10 ]

Author(s):

Vitor F. Ferreira*, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G. S. Lima and Fernando de C. da Silva   Pages 1073 - 1085 ( 13 )

Abstract:


Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases.

Objective: The aim of this review was to provide an overview of the quinones that have become drugs for several therapeutic applications.

Methods: We have comprehensively and critically discussed all the information available in the literature about quinone-based drugs.

Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses.

Conclusion: A number of studies related to quinone drugs for different pharmaceutical uses show that the interest in new applications is still increasing in recent years.

Keywords:

Atovaquone, buparvaquone, parvaquone, mitomycins, doxorubicin, valrubicin, mitoxantrone.

Affiliation:

Universidade Federal Fluminense, Faculdade de Farmácia, Departamento de Tecnologia Farmacêutica, 24241-000, Niterói, RJ,, Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Campus do Valonguinho, 24020-150 Niterói, Universidade Federal Fluminense, Faculdade de Farmácia, Departamento de Tecnologia Farmacêutica, 24241-000, Niterói, RJ,, Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Campus do Valonguinho, 24020-150 Niterói, Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Campus do Valonguinho, 24020-150 Niterói



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