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Current Status of Virtual Screening as Analysed by Target Class

[ Vol. 2 , Issue. 1 ]


Martin J. Stoermer   Pages 89 - 112 ( 24 )


In silico virtual screening for drug discovery has become a hot topic in medicinal chemistry research during the last 5 years, growing from a largely academic pursuit concerned principally with validating the methods used, to a major early-stage technique for lead discovery in the pharmaceutical industry. In this review we highlight a few recent successes in ligand docking associated with virtual screening, paying particular attention to four major target classes of pharmaceutical interest (G Protein-Coupled receptors, nuclear hormone receptors, kinases, proteases). We also discuss some emerging trends in the field, some common limitations, and how they are being overcome.


Virtual screening, docking, kinase, GPCR, protease, receptors, review


Centre for Drug Design andDevelopment, Institute for Molecular Bioscience, University of Queensland,Brisbane, Qld, 4072, Australia.

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