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Discovery of Potential Sorbitol Dehydrogenase Inhibitors from Virtual Screening

[ Vol. 2 , Issue. 3 ]

Author(s):

Ossama El-Kabbani, Deborah A. Carper, Takeshi Iwata and Connie Darmanin   Pages 239 - 242 ( 4 )

Abstract:


Sorbitol dehydrogenase (SDH) is the second enzyme in the polyol pathway of glucose metabolism and is a possible target for the treatment of the complications of diabetes. In this study the molecular modelling program DOCK was used to analyse 249,071 compounds from the National Cancer Institute Database and predict those with high affinity for SDH. From a total of 21 tested the 7 compounds including flavin adenine dinucleotide disodium hydrate, (+)- Amethopterin, 3-hydroxy-2-napthoic(2-hydroxybenzylidene) hydrazide, folic acid, N-2,4-dinitrophenyl-L-cysteic acid, Vanillin azine and 1H-indole-2,3-dione,5-bromo-6-nitro-1-(2,3,4-tri-O-acetyl-α-L-arabinopyranosyl)-(9Cl), were shown to inhibit SDH and displayed IC50 values of 0.192 μM, 1.1 μM, 1.2 μM, 4.5 μM, 5.3 μM, 7 μM and 28 μM, respectively. These compounds may aid the design of pharmaceutical agents for the treatment of diabetes complications.

Keywords:

SDH inhibitor, Zn atom, NCI database, spectrophotometer, DOCK program

Affiliation:

Department of MedicinalChemistry, Victorian College of Pharmacy, Monash University (ParkvilleCampus), Parkville, Victoria 3052, Australia.



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