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Article Details


Retinoids in Clinical Use

[ Vol. 2 , Issue. 4 ]

Author(s):

Vincent C. O. Njar, Lalji Gediya, Puranik Purushottamachar, Panka Chopra, Aashvini Belosay and Jyoti B. Patel   Pages 431 - 438 ( 8 )

Abstract:


Retinoids have been investigated for their therapeutic potential for the past 3 decades. They have a reputation for being both beneficial in the treatment of several diseases and detrimental due to toxic and/or teratogenic side effects. The purpose of this review is to highlight retinoids that are currently used in the clinic. We also discuss their mechanisms of action and research strategies to develop new and safer retinoid-based therapies.

Keywords:

Retinoids, rexinoids, retinoic acid metabolism blocking agents (RAMBAs), RAR/RXR, clinical utility

Affiliation:

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine,Baltimore, MD 2101-1559, USA.



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