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Folic Acid as a Fenton-modulator: Possible Physiological Implication

[ Vol. 2 , Issue. 4 ]

Author(s):

Subrata Chattopadhyay, Birija S. Patro, Soumyakanti Adhikari and Tulsi Mukherjee   Pages 407 - 413 ( 7 )

Abstract:


Acting as a redox switch, folic acid (1) might be a promising iron modulator to protect cellular machinery against oxidative stress and iron overload. The vitamin 1 can directly control the iron concentration by oxidizing it even if present in chelated forms. In addition, during its role as a reducing agent for the biologically relevant reactive oxygen species (ROS), it furnishes 6-formyl pterin. This folate-derived intermediate possesses a stronger Fe2+-oxidizing capacity than 1. Thus, compound 1 can reduce the iron toxicity in two ways. Although, the Fe2+-oxidizing capacity is nullified in the presence of a strong biological reductant like ascorbic acid, this property may play a predominant role during pathogenesis when the cellular ascorbic acid levels deplete significantly. The iron-modulatory property of 1 was also confirmed with the L929 mouse fibroblast cell line.

Keywords:

ferrozine assay, Oxidative degradation, intracellular folate pool, Deoxyribose Assay, Iron chelation

Affiliation:

Bio-Organic Division,Bhabha Atomic Research Centre, Mumbai - 400 085, India.



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