H. Cerecetto, M. Gonzalez, M. L. Lavaggi, M. A. Aravena, C. Rigol, C. Olea-Azar, A. Azqueta, A. Lopez de Cerain, A. Monge and A. M. Bruno Pages 511 - 521 ( 11 )
The synthesis and evaluation as hypoxic selective cytotoxins of new derivatives of 2-amino or 2- hydroxyphenazine 5,10-dioxide are described. The compounds were developed as structural analogs of other bioreductive compounds and its in vitro cytotoxicities on V79 cells under hypoxic and aerobic conditions were determined. To gain insight into its mechanism of action electrochemical behavior, interaction with DNA experiments and QSAR studies were performed.
Phenazine 5, 10-dioxide derivatives, bioreductive compounds, DNA, cyclic voltammetry
Departamento de Quimica Organica, Facultad de Quimica-Facultad de Ciencias, Universidad de la Republica, Igua 4225, 11400 Montevideo, Uruguay.