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Cellular Pharmacology, Antineoplastic Activity and Low In Vivo Toxicity of a Carboxylato-Bridged Platinum(II) Complex bis(acetato)diammine-bis-μ-acetato diplatinum (II) Dihydrate

[ Vol. 3 , Issue. 2 ]

Author(s):

Georgi Momekov, Spiro Konstantinov, Margarita Topashka-Ancheva, Adriana Bakalova, Sonja Arpadjan and Margarita Karaivanova   Pages 157 - 165 ( 9 )

Abstract:


The dinuclear platinum complex bis(acetato)diammine-bis-μ-acetato diplatinum (II) dihydrate has been previously shown to exert profound cytotoxicity in diverse tumor cell lines, while being far less detrimental than the clinically applied platinum drugs against some susceptible to platinum toxicity non-malignant cellular populations. In the present study we report the investigation of the cellular accumulation kinetics and apoptosis induction of the dinuclear complex in K-562, its potent in vivo antineoplastic activity against L1210 leukemia and Lewis lung carcinoma tumor models and its lower nephrotoxicity, myelosuppresive potential and clastogenicity in vivo relative to cisplatin.

Keywords:

Dinuclear platinum complexes, K-562, L-1210 leukemia, Lewis lung carcinoma, nephrotoxicity, genotoxicity

Affiliation:

Lab. of Cellular and Molecular Pharmacology, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Medical University-Sofia, Bulgaria.



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