R. Hackett and P.C.A. Kam Pages 333 - 345 ( 13 )
Botulinum toxin is used as first line therapy for some muscular disorders, and is efficacious in treating hypersecretory and some pain syndromes. When used appropriately it has a good safety profile. It has been evaluated in treating a number of conditions that as yet do not have obvious effective or beneficial treatment. With the greater acceptance and use of botulinum toxin therapy for cosmetic purposes, botulinum toxin use will increase. An understanding of the pharmacology, and potential adverse effects is essential for the physician when managing patients having or who would benefit from botulinum toxin therapy.
Botulinum toxin, botulism, neurotoxin, neuromuscular transmission
Nuffield Professor of Anaesthetics,Univ of Sydney, Dept of Anaesthetics, Royal Prince Alfred Hospital,Missenden Road, Camperdown, NSW 2050, Australia.