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Synthesis of A/B-Ring Partial Analogs of Bruceantin as Potential Antimalarial Agents

[ Vol. 1 , Issue. 1 ]


Z. Guo, S. Vangapandu, A. Nimrod, L. A. Walker and R. D. Sindelar   Pages 3 - 11 ( 9 )


Bruceantin (1), a classical quassinoid with the highest reported antimalarial activity among the quassinoids examined thus far, was selected as a natural product lead for the design of a series of A/B-ring analogs. A viable strategy for the synthesis of the series was developed. The functionalized A-ring and the C-15 ester moiety in bruceantin are incorporated in all designed compounds. The preliminary bioassay results will be discussed in detail.


bruceantin, partial analogs, bioassay, structure activity relationships, antileukemic and antimalarial activities


Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, B. C., V6T1Z3, Canada.

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