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Synthesis of A/B-Ring Partial Analogs of Bruceantin as Potential Antimalarial Agents

[ Vol. 1 , Issue. 1 ]

Author(s):

Z. Guo, S. Vangapandu, A. Nimrod, L. A. Walker and R. D. Sindelar   Pages 3 - 11 ( 9 )

Abstract:


Bruceantin (1), a classical quassinoid with the highest reported antimalarial activity among the quassinoids examined thus far, was selected as a natural product lead for the design of a series of A/B-ring analogs. A viable strategy for the synthesis of the series was developed. The functionalized A-ring and the C-15 ester moiety in bruceantin are incorporated in all designed compounds. The preliminary bioassay results will be discussed in detail.

Keywords:

bruceantin, partial analogs, bioassay, structure activity relationships, antileukemic and antimalarial activities

Affiliation:

Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, B. C., V6T1Z3, Canada.



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