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Inhibitory Feature of the Proprotein Convertases Prosegments

[ Vol. 4 , Issue. 2 ]

Author(s):

Abdel-Majid Khatib, Yannick Bontemps, Marion Lapierre, Geraldine Siegfried and Fabien Calvo   Pages 116 - 120 ( 5 )

Abstract:


The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.

Keywords:

Proprotein convertases, prosegments, inhibitors, processing, maturation, substrates

Affiliation:

Laboratoire de Pharmacologie Experimentale et Clinique, INSERM U 716, Equipe AVENIR, Institut de Genetique Moleculaire, 27 rue Juliette Dodu, 75010 Paris, France.



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