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Comparative Antiviral (HIV) Photoactivity of Metalized meso-Tetraphenylsulfonated Porphyrins

[ Vol. 4 , Issue. 2 ]

Author(s):

Franklin Vargas, Carlos Rivas, Tamara Zoltan, Liliana Padron, Carla Izzo, Veronica Lopez, Lubimar Gomez, Flor Pujol, Hector Rangel, Domingo Garzaro and Rona Fabbro   Pages 138 - 145 ( 8 )

Abstract:


We have carried out the study of the photochemical properties of a series of synthetic mesotetraphenylsulfonated porphyrins (TPPMS4) bonded to several metal ions such as: Cu(II), Zn(II), Pd(II), Mn(II), Fe(III), Ni(II) and Co(II) for the optimization of their clinical applications as antiviral agents against the human immunodeficiency virus (HIV-1) as well as the study of the in vitro antiviral photoinactivation mechanisms with future application in blood sterilization. A selective inhibition has been determined in the viral growth (HIV-1) when this is irradiated in the presence of the complex TPPFeS4 and TPPMnS4 (photosensitizer-mediated Type I reaction) as well as in the 1O2- mediated (Type II reaction) in the presence of TPPPdS4 and TPPZnS4, remaining cellular viability unaltered in each case.

Keywords:

meso-Tetraphenylsulfonated porphyrins, HIV, metallo porphyrins, photoinactivation, phototherapy, phototoxicity, photosensitizer, antiviral, singlet oxygen.

Affiliation:

Instituto Venezolano de Investigaciones Cientificas I.V.I.C., Centro de Quimica, Lab. Fotoquimica, carretera Panamericana km 11, Altos de Pipe, Caracas 1020-A,. Apartado 21827, Venezuela.



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