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Comparative Antiviral (HIV) Photoactivity of Metalized meso-Tetraphenylsulfonated Porphyrins

[ Vol. 4 , Issue. 2 ]


Franklin Vargas, Carlos Rivas, Tamara Zoltan, Liliana Padron, Carla Izzo, Veronica Lopez, Lubimar Gomez, Flor Pujol, Hector Rangel, Domingo Garzaro and Rona Fabbro   Pages 138 - 145 ( 8 )


We have carried out the study of the photochemical properties of a series of synthetic mesotetraphenylsulfonated porphyrins (TPPMS4) bonded to several metal ions such as: Cu(II), Zn(II), Pd(II), Mn(II), Fe(III), Ni(II) and Co(II) for the optimization of their clinical applications as antiviral agents against the human immunodeficiency virus (HIV-1) as well as the study of the in vitro antiviral photoinactivation mechanisms with future application in blood sterilization. A selective inhibition has been determined in the viral growth (HIV-1) when this is irradiated in the presence of the complex TPPFeS4 and TPPMnS4 (photosensitizer-mediated Type I reaction) as well as in the 1O2- mediated (Type II reaction) in the presence of TPPPdS4 and TPPZnS4, remaining cellular viability unaltered in each case.


meso-Tetraphenylsulfonated porphyrins, HIV, metallo porphyrins, photoinactivation, phototherapy, phototoxicity, photosensitizer, antiviral, singlet oxygen.


Instituto Venezolano de Investigaciones Cientificas I.V.I.C., Centro de Quimica, Lab. Fotoquimica, carretera Panamericana km 11, Altos de Pipe, Caracas 1020-A,. Apartado 21827, Venezuela.

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