Scott E. Harpstrite, Silvia D. Collins, Ana Oksman, Daniel E. Goldberg and Vijay Sharma Pages 392 - 395 ( 4 )
Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 μM against CQ-resistant Dd2 strains.
Naphthalene-amine, Schiff-base phenol, antimalarials, chloroquine-resistance, P. falciparum
Mallinckrodt Institute of Radiology, Washington University Medical School, 510 S. Kingshighway Blvd., Box 8225, St. Louis, MO 63110, USA.