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Synthesis, Characterization, and Antimalarial Activity of Novel Schiff-Base-Phenol and Naphthalene-Amine Ligands

[ Vol. 4 , Issue. 4 ]

Author(s):

Scott E. Harpstrite, Silvia D. Collins, Ana Oksman, Daniel E. Goldberg and Vijay Sharma   Pages 392 - 395 ( 4 )

Abstract:


Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 μM against CQ-resistant Dd2 strains.

Keywords:

Naphthalene-amine, Schiff-base phenol, antimalarials, chloroquine-resistance, P. falciparum

Affiliation:

Mallinckrodt Institute of Radiology, Washington University Medical School, 510 S. Kingshighway Blvd., Box 8225, St. Louis, MO 63110, USA.



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