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Derivatives of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic Acid as Novel Fibrinogen Receptor Antagonists

[ Vol. 5 , Issue. 2 ]

Author(s):

Olga L. Malovichko, Andrei A. Krysko, Tatyana A. Kabanova, Sergei A. Andronati, Vladimir I. Grishkovets, Vadim V. Kachala and Denis A. Panov   Pages 158 - 164 ( 7 )

Abstract:


It has been proposed a novel method for obtaining of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid as Argmimetic within the framework of search for novel fibrinogen receptor antagonists. New αIIbβ3 antagonists were prepared on a base of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid. Their high antiaggregatory activities in a human platelet rich plasma and ability to block FITC-Fg binding to αIIbβ3 on washed human platelets were estimated.

Keywords:

fibrinogen receptor antagonists, αIIbβ3, RGD mimetics, 1,2,3,4-tetrahydroisoquinoline, platelet aggregation

Affiliation:

Department of Medicinal Chemistry, A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine. 86 Lustdorfskaya doroga, 65080, Odessa, Ukraine.



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