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Synthesis, DNA Binding, Docking and Photoclevage Studies of Novel Benzo[b][1,8]naphthyridines

[ Vol. 5 , Issue. 5 ]

Author(s):

T.R. Ravikumar Naik, H.S. Bhojya Naik, H.R. Prakash Naik, P. J. Bindu, B. G. Harish and V. Krishna   Pages 411 - 418 ( 8 )

Abstract:


The synthesis and docking studies of novel benzo[b][1,8]naphthyridines are described. The docking studies show that the derivatives prefer to bind the AT-rich region of double stranded DNA (ds-DNA). The maximum binding energy -7.16 (kcal/mol) was observed for benzo[b][1,8]naphthyridine-5-thiol 5a and it is a better candidate as an enantioselective binder to ds-DNA than the other derivatives of benzo[b][1,8]naphthyridines. When photoirradiated at 365 nm, benzo[1,8]-naphthyridines have been found to promote the photocleavage of plasmid pUC19 DNA.

Keywords:

Synthesis, DNA minor groove, Photoclevage, Docking studies, Benzo[b][1,8]naphthyridines

Affiliation:

Department of Studies and Research in Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta-577 451, India.



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