Hasina Yasmin, Sharmistha Das, Lutfun Nahar, M. Mehedi Masud, M. Shafikur Rahman, Suvash C. Roy, M. Mukhlesur Rahman, Simon Gibbons, Joydeb K. Kundu, Bidyut K. Datta, Sitesh C. Bachar, A. K. Azad Chowdhury and Satyajit D. Sarker Pages 468 - 473 ( 6 )
6-Fluoro-3-oxo-indan-1-acetic acid (5) and 6-fluoroindan-1-acetic acid (6) were conveniently synthesised from 3-fluorobenzaldehyde in four and five steps, respectively. The structures of these new compounds and two other intermediates, 3-fluorobenzylidine-bis-acetoacetate (2) and 3-fluoro-β-phenyl glutaric acid (3) were elucidated by spectroscopic means, notably, HRMS, 1D and 2D NMR. The analgesic activity of compounds 5 and 6 were assessed by the acetic acid induced writhing in Swiss albino mice.
3-fluorobenzylidine-bis-acetoacetate, 3-fluoro-β-phenyl glutaric acid, 6-fluoro-3-oxo-indan-1-acetic acid, 6-fluoroindan-1-acetic acid, analgesic activity
Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, MM Building, Molineux Street, Wolverhampton WV1 1SB, UK.