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Synthesis and Preliminary Biological Evaluation of Chrysin Derivatives as Potential Anticancer Drugs

[ Vol. 6 , Issue. 1 ]

Author(s):

Xing Zheng, Fei Fei Zhao, Yun Mei Liu, Xu Yao, Zi Tong Zheng, Xing Luo and Duan Fang Liao   Pages 6 - 8 ( 3 )

Abstract:


A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6- trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.

, Synthesis, and, Preliminary, Biological, Evaluation, of, Chrysin, Derivatives, as, Potential, Anticancer, Drugs

Affiliation:

Institute of Pharmacy&Pharmacology, University of South China, Hengyang 421001, China.



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