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Germatranyl Substituted Organotin (IV) Carboxylates: Synthesis Spectroscopic Characterization and Biological Activities

[ Vol. 5 , Issue. 6 ]

Author(s):

U. Salma, Imtiaz-ud-Din, M. Mazhar and Khalid Mohammed Khan   Pages 543 - 548 ( 6 )

Abstract:


Eight new organotin (IV) derivatives of general formula [N(CH2CH2O)3GeCH(R1)CH2COO]4-nSnR2 n, where n = 2, R2 = C2H5 (1-5); R1 = CH3 (1); C6H5 (2); p-CH3C6H4 (3); p-FC6H4(4); p-CH3OC6H4 (5) and n = 3, R2 = CH2C6H5 (6- 8), R1 = CH3 (6); C6H5 (7); p-CH3C6H4 (8) have been synthesized by the reaction of di- or tri-organotin chloride with the corresponding germatranyl (substituted) propionic acid in the appropriate mole ratios using triethylamine as a base. The synthesized compounds were characterized by various spectroscopic techniques such as IR, multi-nuclear (1H, 13C, 119Sn) NMR, 119mSn Mossbauer, along with elemental analyses. They were also screened for in vitro anti-leishmanial activity against promastigotes of leishmania donovani and found some encouraging results.

Keywords:

Germatranes, diethyltin, tribenzyltin, spectroscopy, antileishmanial activity

Affiliation:

Department of Chemistry, Allama Iqbal Open University Islamabad 44000, Pakistan.



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